Section 1: The worldwide status of palliative care
1.1:International progress in the development of palliative medicine, Carlos Centeno, Sheila Payne, and Eduardo Garralda
1.2:Essential medicines for palliative care, Lukas Radbruch and Liliana De Lima
1.3:Human rights issues, Frank Brennan and Liz Gwyther
1.4:Policy in palliative care, Stephen R. Connor
Section 2: The challenge of palliative medicine
2.1:Building definitional consensus in palliative care, Russell K. Portenoy
2.2:Core concepts in palliative care, Nathan I. Cherny and Russell K. Portenoy
2.3:The epidemiology of death and symptoms: Planning for population-based palliative care, Davinia Seah, David Marco, Jennifer Philip, and Megan B. Sands
2.4:Barriers to the delivery of palliative care, Barry Laird, Erna Haraldsdottir, and Charlie Hall
2.5:Ethnic and cultural aspects of palliative and end of life care, Jonathan Koffman and Natalia Calanzani
2.6:Health economics for palliative care, Peter S. Hall, Katharina Diernberger, and Liz Grant
Section 3: Service delivery issues in palliative care
3.1:Specialist palliative care along the trajectory of illness: Issues in the early integration of palliative care, Breffni Hannon, Stein Kaasa, and Camilla Zimmermann
3.2:Palliative care delivery models, Irene J. Higginson
3.3:Palliative medicine in the intensive care unit, Sharon Einav, Nathan I. Cherny, and J. Randall Curtis
3.4:Palliative care in the emergency department, Naomi George and Corita Grudzen
3.5:Palliative care in the nursing home, Jane Phillips and Annmarie Hosie
Section 4: Healthcare professionals in palliative care
4.1:The core team and the extended team, Dagny Faksvåg Haugen, Friedemann Nauck, and Deborah Witt Sherman
4.2:Burnout, compassion fatigue, and moral distress in palliative care, Nathan I. Cherny, Batsheva Werman, and Michael Kearney
4.3:Nursing Education in palliative care, Betty R. Ferrell, Polly Mazanec, Pam Malloy, and Rose Virani
4.4:Social work in palliative care, Terry Altilio, Bridget Sumser, and Nina Laing
4.5:The role of the chaplain in palliative care, George Handzo and Christina Puchalski
4.6:Occupational therapy in palliative care, Maria Denise Pessoa Silva, Fiona Rolls, Lynne White, Tamsin Longley, Jane Murphy, and Jill Cooper
4.7:The role of the creative arts in palliative care, Nigel Hartley
4.8:The role of the dietitian in palliative care, Samantha Cushen and Aoife Ryan
4.9:Physiotherapy in palliative care, Lucy Fettes and Matthew Maddocks
4.10:Speech and language therapy in palliative care, Tim Luckett and Katherine L.P. Reid
4.11:Clinical psychology in palliative care, E. Alessandra Strada
4.12:The contribution of the clinical pharmacist in palliative care, Ebtesam Ahmed
4.13:Medical rehabilitation and the palliative care patient, Andrew Malcom Cole
Section 5: Communication and palliative medicine
5.1:Communication with the patient and family, Thomas LeBlanc and James Tulsky
5.2:Practical considerations including difficult conversations, Susan D. Block
5.3:Advance care planning, Judith Rietjens, Ida Korfage, and Jane Seymour
Section 6: Family and caregiver issues
6.1:Family dynamics in the context of serious illness, Carrie Lethborg and David W. Kissane
6.2:Caregiver burden and distress, Rinat Nissim, Sarah Hales, and Gary Rodin
Section 7: Pain
7.1:Definition and assessment of chronic pain in advanced disease, Lucy N. Wyld, Clare Rayment, and Mike I. Bennett
7.2:Pathophysiology of pain in cancer and other terminal illnesses, Anthony H. Dickenson and Richard Gordon-Williams
7.3:Acute cancer pain syndromes, Nathan I. Cherny
7.4:Chronic cancer pain syndromes, Nathan I. Cherny
7.5:Principles of drug therapy, Ruth Miles, Steven Wanklyn, and Joy Ross
7.6:Opioid therapy: Optimizing analgesic outcomes, Nathan I. Cherny and Marie T. Fallon
7.7:Opioid therapy: Managing risks of abuse, addiction, and diversion, Joseph V. Pergolizzi, Jr., Jo Ann LeQuang, Flaminia Coluzzi, Dean Mariano, Andrew Nicolaou, and Christopher Gharibo
7.8:Non-opioid analgesics, Per Sjøgren, Frank Elsner, and Stein Kaasa
7.9:Adjuvant analgesics: principles of use, Ebtesam Ahmed, Russell K. Portenoy, and Mona Patel
7.10:7.10 Interventional approaches for chronic pain, Robert A. Swarm, Menelaos Karanikolas, Lesley K. Rao, and Rajiv K. Shah
7.11:Neurostimulation in pain management, Helena Knotkova
7.12:Behavioral and psychosocial interventions for pain management, Joseph Winger, Carolyn E. Keeler, and Francis Keefe
7.13:Integrative medicine therapies in pain management, Noah Samuels and Eran Ben-Arye
7.14:Management issues in bone pain, Peter Hoskin
7.15:Management issues in neuropathic pain, Nanna Finnerup and Lise Ventzel
7.16:Management issues in visceral pain, Victor T. Chang
7.17:Management issues in chronic pain following cancer therapy, Judith A. Paice
7.18:Paediatric pain control, Renee McCulloch
Section 8: Gastrointestinal symptoms and disorders
8.1:Dysphagia, dyspepsia, and hiccups, Katherine Clark
8.2:Nausea and vomiting, Saskie Dorman
8.3:Constipation and diarrhoea, Philip J. Larkin
8.4:Jaundice, ascites, and encephalopathy, Alexandra Shingina and Anne M. Larson
8.5:Aetiology, classification, assessment, and treatment of the anorexia-cachexia syndrome, Vickie Baracos and Sharon Watanabe
8.6:Parenteral nutrition, Jann Arends and Florian Strasser
Section 9: Cardio-respiratory symptoms and disorders
9.1:Breathlessness and other respiratory symptoms in palliative care, Miriam Johnson and David C. Currow
9.2:Cough and other pulmonary symptoms, Doris Tse and Kin-Sang Chan
Section 10: Skin and oral symptoms and disorders
10.1:Skin problems in palliative care, Sebastian Probst and Georgina Gethin
10.2:Palliative wound and ostomy care, Charles P. Tilley, Mei R. Fu, Janet H. Van Cleave, Allison R. Most, and Christopher Comfort
10.3:Lymphoedema and oedema of advanced disease, Vaughan Keeley
10.4:Oral care, Andrew N. Davies
Section 11: Genitourinary symptoms and disorders
11.1:Dysuria, frequency, and bladder spasm, Christopher Evans, Jennifer G. Rothschild, Noah Canvasser, and Frederick Meyers
11.2:Obstructive urinary disorders, Noah E. Canvasser, Jennifer G. Rothschild, Frederick J. Meyers and Christopher P. Evans
Section 12: Constitutional symptoms and related disorders
12.1:Fatigue, Sriram Yennurajalingam and Eduardo Bruera
12.2:Sexuality in palliative care: Discussing patient sexuality and intimacy in palliative care, Lauren Kadwell, Jane Ussher, Emilee Gilbert, Janette Perz, and Amanda Hordern
12.3:Sleep disorders, Kyriaki Mystakidou, Efi Parpa, and Eleni Tsilika
12.4:Assessment and management of thrombotic complications, Simon Noble, Nicola Pease, and Nicholas Chinn-Yee
12.5:Assessment and management of bleeding complications in the medically ill, Bill Hulme, Sarah Wilcox, Paul Ashwood, Laura Deacon, Hazel Gilkes, and Victoria Montgomery
Section 13: Psychiatric and psychological symptoms and disorders
13.1:Coping and resilience in palliative medicine, Tzeela Cohen and Simon Wein
13.2:Depression, demoralization, and suicidality, David W. Kissane
13.3:Fear, anxiety, and adjustment disorder in palliative care, Kerry A. Sherman and Christopher J. Kilby
13.4:Delirium, Meera Agar, Yesne Alici, Augusto Caraceni, and William Breitbart
13.5:Bereavement, David W. Kissane
Section 14: Palliative care in cancer
14.1:The oncologist s role in delivering palliative care, Nathan I. Cherny and Stein Kaasa
14.2:Disease-modifying therapies in advanced cancer-medical treatment, Olav Dajani and Karin Jordan
14.3:Radiotherapy in symptom management, Peter Hoskin
14.4:The role of general surgery in the palliative care of patients with cancer, Robert Krouse and Brian Badgwell
14.5:Orthopaedic surgery in the palliation of cancer, Mohamed Yakoub and John Healey
14.6:Integrative oncology in palliative medicine, Eran Ben Arye and Noah Samuels
14.7:Interventional radiology in the palliation of cancer, Tarun Sabharwal, Nicos I. Fotiadis, and Andy Adam
14.8:Neurological problems in advanced cancer, Augusto Caraceni, Fabio Simonetti, and Cinzia Martini
14.9:Endocrine and metabolic complications of advanced cancer, Richella Ryan and Ruth Casey
14.10:Malignant Bowel obstruction, Jason W. Boland and Elaine G. Boland
14.11:Palliative care issues in head and neck cancers, Catriona Mayland and Simon N. Rogers
14.12:Palliative care issues in populations with haematological malignancies, Thomas William LeBlanc and Arjee El-Jawahri
14.13:Anaemia, cytopenias, and thrombosis in palliative medicine, Nancy Zhu and Cynthia Wu
Section 15: Issues in populations with non-cancer illnesses
15.1:HIV/AIDS, Meera Pahuja and Peter Selwyn
15.2:Advanced diseases of the lung, Natasha Smallwood and Nicole Goh
15.3:Advanced heart disease, Steve Pantilat, Patricia Davidson, and Mitch Psotka
15.4:Dementia, Eric Widera, Shaida Talebreza, and Rachelle Emily Bernacki
15.5:Neurological disorders other than dementia, Stefan Lorenzl and Raymond Voltz
15.6:Palliative care and end-stage liver disease, Arpan Patel and Anne Walling
15.7:End-stage kidney disease, Fliss E.M. Murtagh
15.8:Palliative care in catastrophic disasters and humanitarian crises, Anne Wilkinson and Marianne Matzo
Section 16: Issues of the very young and the very old
16.1:Involving children and families when someone important is dying or has died, Erna Haraldsdottir and Sally Paul
16.2:Care of children with advanced illness, Myra Bluebond-Langner, Richard W. Langner, and Ignasi Clemente
16.3:Palliative medicine and care of the elderly, Meera Agar and Jane Phillips
Section 17: Spiritual issues in palliative medicine
17.1:Spiritual issues in palliative medicine, Susan McClement, Genevieve Thompson, and Jamie Penner
17.2:Integration of spiritual care into palliative care service delivery models, Yvan Beaussant, Alexandra Nichipor, and Tracy A. Balboni
Section 18: The terminal phase
18.1:Predicting survival in patients with advanced disease, Christian T. Sinclair
18.2:Physiology of dying, David Hui and Masanori Mori
18.3:Management of the actively dying patient, Judith Lacey and Nathan I. Cherny
Section 19: Ethical issues
19.1:Practical bioethics in the care of patients with advanced illness, Robert C. Macauley
19.2:Requests for futile or inappropriate interventions near the end of life, Alexander A. Kon
19.3:3 Autonomy and shared decision making in a multi-cultural world, Nathan I. Cherny
19.4:Truth-telling and consent, Linda Emanuel, Rebecca Johnson, and Lara Boyken
19.5:Ethics in paediatric palliative care, Richard D.W. Hain
19.6:Ethical issues in physician aid-in-dying, Lars Johan Materstvedt
19.7:Withholding and withdrawing life-sustaining treatment (including artificial nutrition and hydration), Danielle Ko, Hannah Evans-Barns, and Craig Blinderman
19.8:Medical and ethical considerations in palliative sedation at the end of life, Eric L. Krakauer
Section 20: Assessment tools and Informatics
20.1:Palliative care needs assessment tools, Afaf Girgis, Amy Waller, and Breanne Hobden
20.2:Informatics and literature search, Jennifer Tieman and David C. Currow
20.3:Validated assessment tools for psychological, spiritual, and family issues, Madeline Li, Tracy A. Balboni, Rinat Nissim, and Gary Rodin
Section 21: Teaching and training in palliative medicine
21.1:Physicians, Karen Forbes and Jane Gibbins
21.2:Nurses, Geana Paula Kurita and Philip J. Larkin
21.3:Teaching and training in palliative social work, chaplaincy, and pharmacy, Myra Glajchen, George Handzo, and Ebtesam Ahmed
Section 22: Research in palliative medicine
22.1:Research in palliative care, Marianne Hjermstad and Stein Kaasa
22.2:The principles of evidence-based medicine, Miriam Johnson and David C. Currow
22.3:Understanding clinical trials in palliative care research, Pål Klepstad and Stein Kaasa
22.4: Qualitative research, Kate Flemming
22.5:Research into psychosocial issues, David K. Kissane, Christopher H. Grossman, and Clare O'Callaghan
22.6:Ethical issues in palliative care research, Tyler Tate and David Casarett
22.7:Quality of life and patient-reported outcome measures, Jon Håvard Loge and Stein Kaasa
22.8:Health services research in palliative and end-of-life care, Tinne Smets and Luc Deliens
22.9:Clinical audit in palliative medicine, Irene J. Higginson and Mevhibe Hocaoglu
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