Through six outstanding and award-winning editions, Ryan’s Retina has offered unsurpassed coverage of this complex subspecialty—everything from basic science through the latest research, therapeutics, technology, and surgical techniques. The fully revised 7th Edition, edited by Drs. SriniVas R. Sadda, Andrew P. Schachat, Charles P. Wilkinson, David R. Hinton, Peter Wiedemann, K. Bailey Freund, and David Sarraf, continues the tradition of excellence, balancing the latest scientific research and clinical correlations and covering everything you need to know on retinal diagnosis, treatment, development, structure, function, and pathophysiology. More than 300 global contributors share their knowledge and expertise to create the most comprehensive reference available on retina today.
Key Features
Features sweeping content updates, including new insights into the fundamental pathogenic mechanisms of age-related macular degeneration, advances in imaging including OCT angiography and intraoperative OCT, new therapeutics for retinal vascular disease and AMD, novel immune-based therapies for uveitis, and the latest in instrumentation and techniques for vitreo-retinal surgery.
Includes five new chapters covering Artificial Intelligence and Advanced Imaging Analysis, Pachychoroid Disease and Its Association with Polypoidal Choroidal Vasculopathy, Retinal Manifestations of Neurodegeneration, Microbiome and Retinal Disease, and OCT-Angiography.
Includes more than 50 video clips (35 new to this edition) highlighting the latest surgical techniques, imaging guidance, and coverage of complications of vitreoretinal surgery. New videos cover Scleral Inlay for Recurrent Optic Nerve Pit Masculopathy, Trauma with Contact Lens, Recurrent Retinal Detachment due to PVR, Asteroid Hyalosis, and many more.
Contains more than 2,000 high-quality images (700 new to this edition) including anatomical illustrations, clinical and surgical photographs, diagnostic imaging, decision trees, and graphs.
Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.
Through six outstanding and award-winning editions, Ryan’s Retina has offered unsurpassed coverage of this complex subspecialty—everything from basic science through the latest research, therapeutics, technology, and surgical techniques. The fully revised 7th Edition, edited by Drs. SriniVas R. Sadda, Andrew P. Schachat, Charles P. Wilkinson, David R. Hinton, Peter Wiedemann, K. Bailey Freund, and David Sarraf, continues the tradition of excellence, balancing the latest scientific research and clinical correlations and covering everything you need to know on retinal diagnosis, treatment, development, structure, function, and pathophysiology. More than 300 global contributors share their knowledge and expertise to create the most comprehensive reference available on retina today.
VOLUME 1 PART 1 Retinal Imaging and Diagnostics 1. Fluorescein Angiography: Basic Principles and Interpretation 2. Clinical Applications of Diagnostic Indocyanine Green Angiography 3. Optical Coherence Tomography 4. Optical Coherence Tomography Angiography (OCTA) 5. Autofluorescence Imaging 6. Widefield Imaging 7. Advanced Imaging Technologies 8. Artificial Intelligence and Advanced Imaging Analysis 9. Clinical Electrophysiology 10. Diagnostic Ophthalmic Ultrasound 11. Color Vision and Night Vision 12. Visual Acuity and Contrast Sensitivity 13. Visual Fields in Retinal Disease PART 2 Basic Science and Translation to Therapy SECTION 1 Anatomy and Physiology 14. The Development of the Retina 15. Function and Anatomy of the Mammalian Retina 16. Structure and Function of Rod and Cone Photoreceptors 17. Cell Biology of the Retinal Pigment Epithelium 18. Glial Cells of the Fovea 19. Retinal and Choroidal Vasculature: Retinal Oxygenation 20. Mechanisms of Normal Retinal Adhesion 21. Structure, Function, and Pathology of Bruch’s Membrane 22. Vitreous and Vitreoretinal Interface SECTION 2 Basic Mechanisms of Injury in the Retina 23. Mechanisms of Oxidative Stress in Retinal Injury 24. Mechanisms of Endoplasmic Reticulum Stress in Retinal Disease 25. Cell Death, Apoptosis, and Autophagy in Retinal Injury 26. Inflammation and Immune Responses in Retinal Health and Disease 27. Basic Mechanisms of Pathologic Retinal and Choroidal Angiogenesis 28. Blood–Retinal Barrier, Immune Privilege, and Autoimmunity 29. Mechanisms of Diabetic Macular Edema and Therapeutic Approaches 30. Cellular Effects of Detachment and Reattachment on the Neural Retina and the Retinal Pigment Epithelium 31. Retinal Manifestations of Neurodegeneration: A Focus on Alzheimer Disease SECTION 3 Genetics 32. Genetic Mechanisms of Retinal Disease 33. Mitochondrial Genetics of Retinal Disease 34. Epigenetic Mechanisms of Retinal Disease 35. Microbiome and Retinal Disease SECTION 4 Translational Basic Science 36. Gene Therapy for Retinal Disease 37. Stem Cells and Cellular Therapy for Retinal Degenerative Diseases 38. Nanomedicine in Ophthalmology 39. Neuroprotection 40. Drug Delivery 41. Retinal Laser Therapy: Biophysical Basis and Applications
VOLUME 2 Medical Retina SECTION 1 Retinal Degenerations and Dystrophies 42. Macular Dystrophies 43. Retinitis Pigmentosa and Allied Disorders 44. Abnormalities of Rod and Cone Function 45. Hereditary Vitreoretinal Degenerations 46. Hereditary Choroidal Dystrophies SECTION 2 Retinal Vascular Disease 47. Diabetic Retinopathy: Etiologic Mechanisms and Genetics 48. Diabetes Mellitus 49. Nonproliferative Diabetic Retinopathy and Diabetic Macular Edema 50. Proliferative Diabetic Retinopathy 51. Telescreening for Diabetic Retinopathy 52. Hypertension 53. Retinal Artery and Capillary Occlusions 54. Acquired Retinal Macroaneurysms 55. Branch Retinal Vein Occlusion 56. Central Retinal Vein Occlusion 57. Macular Telangiectasia Type 2 58. Coats Disease 59. Hemoglobinopathies 60. Radiation Retinopathy 61. Ocular Ischemic Syndrome 62. Systemic Coagulopathy Syndromes 63. Pediatric Retinal Vascular Diseases SECTION 3 Choroidal Vascular/Bruch’s Membrane Disease 64. Epidemiology and Risk Factors for Age-Related Macular Degeneration 65. Pathogenesis of Age-Related Macular Degeneration 66. Age-Related Macular Degeneration: Non-Neovascular Early AMD, Intermediate AMD, and Geographic Atrophy 67. Neovascular Age-Related Macular Degeneration 68. Pharmacotherapy of Age-Related Macular Degeneration 69. Pathologic Myopia 70. Angioid Streaks 71. Ocular Histoplasmosis 72. Pachychoroid Disease and Its Association With Polypoidal Choroidal Vasculopathy 73. Central Serous Chorioretinopathy 74. Uveal Effusion Syndrome and Hypotony Maculopathy SECTION 4 Inflammatory Disease/Uveitis Inflammation 75. Sympathetic Ophthalmia 76. Vogt–Koyanagi–Harada Disease 77. White Spot Syndromes and Related Diseases 78. Autoimmune Retinopathies 79. Sarcoidosis 80. Intermediate Uveitis 81. Rheumatic Disease Infections 82. HIV-Associated Infections 83. Mycobacterial Infections 84. Eales Disease 85. Spirochetal Infections 86. Ocular Toxoplasmosis 87. Helminthic Disease 88. Endogenous Endophthalmitis: Bacterial and Fungal 89. Acute Retinal Necrosis Syndrome 90. Drug Toxicity of the Posterior Segment 91. Photic Retinal Injuries: Mechanisms, Hazards, and Prevention 92. Traumatic Chorioretinopathies 93. Retinal and Choroidal Disorders in Pregnancy (Pregnancy-Related Diseases) 94. Optic Disc Anomalies, Drusen, Pits, Hypoplasia, and Associated Retinal Pathology 95. Retina-Related Clinical Trials: A Resource Bibliography
VOLUME 3 PART 1 Surgical Retina SECTION 1 The Pathophysiology of Retinal Detachment and Associated Problems 96. Pathogenetic Mechanisms of Retinal Detachment 97. Nonrhegmatogenous Retinal Detachment 98. Degenerative Retinoschisis 99. Pathogenesis of Proliferative Vitreoretinopathy 100. Pathophysiology of Ocular Trauma SECTION 2 Retinal Reattachment: General Surgical Principles and Techniques 101. The Biomechanics of Scleral Buckles in the Treatment of Retinal Detachment 102. Techniques of Scleral Buckling 103. Principles and Techniques of Vitreoretinal Surgery 104. Intraoperative OCT Imaging 105. Primary Vitrectomy in Rhegmatogenous Retinal Detachment 106. Pneumatic Retinopexy 107. Special Adjuncts to Treatment 108. Optimal Procedures for Retinal Detachment Repair 109. Prevention of Retinal Detachment SECTION 3 Complicated Forms of Retinal Detachment 110. Proliferative Vitreoretinopathy 111. Retinotomies and Retinectomies 112. Giant Retinal Tear 113. Surgery for Ocular Trauma: Principles and Techniques of Treatment 114. Surgery for Proliferative Diabetic Retinopathy 115. Management of Combined Inflammatory and Rhegmatogenous Retinal Detachment 116. High Myopia and the Vitreoretinal Complications 117. Surgical Management of Retinopathy of Prematurity 118. Surgery for Pediatric Vitreoretinal Disorders SECTION 4 Vitreous Surgery for Macular Disorders 119. Epiretinal Membranes, Vitreoretinal Traction, Cystoid Macular Edema, and Submacular Hemorrhage 120. Macular Hole 121. Retinal Pigment Epithelium and Choroid Translocation in Patients With Age-Related Macular Degeneration SECTION 5 Vitreous Surgery: Additional Considerations 122. Infectious Endophthalmitis 123. Diagnostic and Therapeutic Vitrectomy for Uveitis 124. Vitreous, Retinal, and Choroidal Biopsy 125. Transplantation Frontiers 126. Artificial Vision 127. Pharmacology During Surgery 128. Complications and Challenges in Vitreoretinal Surgery PART 2 Tumors of the Retina, Choroid, and Vitreous SECTION 1 Tumors of the Retina 129. Retinoblastoma 130. Cavernous Hemangioma 131. Hemangioblastoma of the Retina and von Hippel–Lindau Disease 132. Tuberous Sclerosis and the Eye 133. Phakomatoses 134. Retinal Metastases 135. Remote Effects of Cancer: Paraneoplastic Autoimmune Retinopathies 136. Optic Disc Melanocytoma 137. Congenital Hypertrophy of the Retinal Pigment Epithelium 138. Combined Hamartoma of the Retinal Pigment Epithelium and Retina SECTION 2 Tumors of the Choroid 139. Choroidal Nevi 140. Epidemiology of Posterior Uveal Melanoma 141. Prognosis of Posterior Uveal Melanoma 142. Molecular Genetics of Choroidal Melanoma 143. Pathology of Choroidal Melanoma 144. Overview of Management of Posterior Uveal Melanoma 145. Enucleation for Choroidal Melanomas 146. Brachytherapy for Choroidal Melanoma 147. Charged-Particle Irradiation of Uveal Melanoma 148. Surgical Resection of Choroidal Melanoma 149. Laser Treatment of Choroidal Melanoma 150. Systemic Evaluation and Management of Patients With Metastatic Uveal Melanoma 151. Collaborative Ocular Melanoma Study 152. Choroidal Metastases 153. Choroidal Osteoma 154. Circumscribed Choroidal Hemangioma SECTION 3 Hematologic and Miscellaneous Tumors 155. Miscellaneous Uveal Tumors 156. Leukemias and Lymphomas 157. Primary Vitreoretinal Lymphoma Index
Author
Edited by SriniVas R. Sadda, MD, Andrew P. Schachat, MD, Charles P. Wilkinson, MD , David R. Hinton, MD, Peter Wiedemann, MD, K. Bailey Freund, MD and David Sarraf, MD
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